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Table 3 List of genes up or down-regulated 1.5 fold in the 12 most significant canonical pathways according to Ingenuity Pathways Analysis

From: Gene Expression in Temporal Lobe Epilepsy is Consistent with Increased Release of Glutamate by Astrocytes

Canonical Pathways

Up-regulated Genes

Down-regulated Genes

Glutamate Receptor Signaling

 

CALM3, DLG4, GRIA1, GRIA2, GRIA3, GRIN1, GRM5, HOMER1, SLC1747

GABA Receptor Signaling

 

DNM1, GABRA2, GABRA5, GABRB3, GABRG2, GPR51, NSF

Antigen Presenting Pathway

CD74, HLA-DPA1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-E

 

G-protein-coupled Receptor Signaling

NFKBIA

DUSP4, DUSP6, GRM5, HTR2A, MAPK1, PDE2A, PLCB1, PRKAR2B, PRKCB1, PTK2B, RGS2, RGS4, RGS7

Chemokine signaling

CCL2, CXCR4,

CALM3, MAPK1, PLCB1, PRKCB1, PTK2B

Glycosphingolipid Metabolism

GAL3ST1, GALC, PPAP2C, UGT8

SMPD3

Prostaglandin and Leukotriene Metabolism

AKR1C3, CYP4F3, PRDX6, PTGDS

PTGS2, YWHAZ

Amyloid Processing

CAPN2, PSEN1

MAPK1, PRKAR2B

Integrin Signaling

ARHGAP5, CAPN2, COL1A1, ITGB4, LAMA4, RHOQ

ACTN1, ARF3, MAP2K4, MAPK1, PAK3

Purine Metabolism

ADCY7, AK1, ATP6V0E, ENPP2, GMPR, PDE8A, TJP2

AK5, ATP6V1G2, DLG3, DLG4, PDE2A

IL Signaling

COL1A1, NFKBIA

MAP2K4, MAPK1, PTK2B

Apoptosis Signaling

CAPN2, NFKBIA

MAP2K4, MAPK1

  1. Abbreviations: ACTN1, Actinin α 1; ADCY7, Adenyl cyclase 7; AK1, Adenylate kinase 1; AK5, Adenyl kinase 5; AKR1C3, Ado-keto reductase family 1, member C3; ARF3, ADP-ribosylation factor 3; ARHGAP5, Rho GTPase activating protein 5; ATP6V0E, ATPase, H + transporting, lysosomal V0 subunit E; ATP6V1G2, ATPase, H + transporting, lysosomal 13kDa, V1 subunit G isoform 2; CALM3, Calmodulin 3 (phosphorylase kinase, delta); CAPN2, Calpain 2; CCL2, Chemokine (C-C motif) ligand 2; CD74, CD74 antigen (invariant polypeptide of MHLA, class II antigen-associated); COL1A1, Collagen α 1(I) chain precursor; CXCR4, Chemokine (C-X-C motif) receptor 4; CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3; DLG3, Discs, large homolog 3 (neuroendocrine-dlg, Drosophila); DLG4, Discs, large homolog 4 (Drosophila); DNM1, Dynamin 1; DUSP4, Dual specificity phosphatase 4; ENPP2, Ectonucleotide pyrophosphatase/phosphodiesterase 2; GABRA2, γ-aminobutyric acid (GABA) A receptor, α 2; GABRA5, γ-aminobutyric acid (GABA) A receptor, α 5; GABRB3, γ-aminobutyric acid (GABA) A receptor, β 3; GABRG2, γ-aminobutyric acid (GABA) A receptor, γ2; GALC, Galactosylceramidase; GAL3ST1, Galactose-3-Osulfotransferase 1; GMPR, Guanosine monophosphate reductase; GPR51, G protein-coupled receptor 51; GRIA1, Glutamate receptor, ionotropic, AMPA 1; GRIA3, Glutamate receptor, ionotropic, AMPA 3; GRIN1, Glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRM5, Glutamate receptor, metabotropic 5; HLA-DPA1, Major histocompatibility complex, class II, DP α 1; HLA-DQA1, Major histocompatibility complex, class II, DQ α 1; HLA-DRA, Major histocompatibility complex, class II, DR alpha; HLA-DRB1, Major histocompatibility complex, class II, DP α 1; HLA-DRB3, Major histocompatibility complex, class II, DP α 3; HLA-E, Major histocompatibility complex, class I, E; HOMER1, Homer homolog 1 (Drosophila); HTR2A, 5-hydroxytryptamine (serotonin) receptor 2A; ITGB4, Integrin β 4; LAMA4, Laminin, α 4; MAP2K4, Mitogen-activated protein kinase kinase 4; MAPK1, Mitogen-activated protein kinase 1; NFKBIA, Nuclear factor kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NSF, N-ethylmaleimide-sensitive factor; PAK3, p21 (CDKN1A)-activated kinase 3; PDE2A, Phosphodiesterase 2A, cGMP-stimulated; PDE8A, Phosphodiesterase 8A; PLCB1, Phospholipase C, β 1 (phosphoinositide-specific); PPAP2C, Phosphatidic acid phosphatase type 2C; PRDX6, Peroxiredoxin 6; PRKAR2B, Protein kinase, cAMP-dependent, regulatory, type II, beta; PRKCB1, Protein kinase C, β 1; PSEN1, Presenilin 1 (Alzheimer disease 3); PTGDS, Prostaglandin D2 synthase; PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PTK2B, Protein tyrosine kinase 2 beta; RGS2, Regulator of G-protein signaling 2, 24kDa; RGS4, Regulator of G-protein signaling 4; RGS7, Regulator of G-protein signaling 7; RHOQ, Ras homolog gene family, member Q; SLC1747, Solute carrier family 14 (urea transporter), member 1 (Kidd blood group); SMPD3, Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II); TJP2, Tight junction protein 2; UGT8, UDP glycosyltransferase 8; YWHAZ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta.
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Molecular Medicine

ISSN: 1528-3658