Gene and Protein Expressions Induced by 17β-estradiol and Parathion in Cultured Breast Epithelial Cells

Table 1 Differentially expressed genes in estrogen and parathion-treated cells

Array Location	Gene Name (Symbol) Function	MCF-10F^a	E2^bcd	Parathion^bcd	E2+ parathion^bcd
8	Cyclin A2 (CCN1, CCNA2)	-	↓	↓	↓
11	Regulation of cell cycle Cyclin C (CCNC)	_	-	↑	-
14	Regulation of cell cycle Cyclin D3 (CCND3) Regulation of cell cycle	-	↑	↑	-
29	CDC18L/HsCDC18(CDC6) Regulation of cell cycle	-	-	↑	-
36	CAP20/CDKN1 (CDKN1A) Regulation of cell cycle	-	-	↑	-
41	INK4C/p18 (CDKN2C) Cell cycle arrest	-	↓	↓	-
44	CKS1/PNAS-16 (CKS1B) G2&G2M regulation	-	↓	↓	-
67	MCG40308/Mis5 (MCM6) S phase & DNA replication	-	↑	-	↑
69	Hdm2 (MDM2)	-	-	-	↑

^aBoth up regulated and down regulated of gene expression over 2.0 to 5.0 fold alterations are taken into consideration.
^bUp arrow indicates the up-regulated expression of that gene with respect to control MCF-10F.
^cDown arrow indicates the down-regulated expression of that gene with respect to control MCF-10F.
^d(−) Indicates no change in expression of that gene with respect to control MCF-10F.

ISSN: 1528-3658