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Table 4 Multivariable Models of RRV Predictors for Inflammatory Markers, Including Covariates and Current Medication Use, Diabetes, and Hypertension

From: RR Interval Variability Is Inversely Related to Inflammatory Markers: The CARDIA Study

 

Inflammatory markers

 

In (CRP mg/L)

In (IL6 pg/mL)

N in Models

734

 

678

 

Measures of RRV

Coeffa

p

Coeffa

P

HF adjusted for respiratory rateb

−0.0866

0.0118

−0.0401

0.2353

Black

0.0248

0.5027

0.0975

0.0076

Female

0.0886

0.0116

−0.0073

0.8321

Age (years)

−0.0428

0.2089

0.0241

0.4734

> HS

−0.0521

0.1348

−0.0884

0.0096

Current smoker

0.1278

0.0004

0.0558

0.1118

Ex-smoker

0.0317

0.3571

−0.0063

0.8524

Physical activity score

−0.0307

0.3781

−0.0643

0.0628

SBP (mmHg)

−0.0272

0.4915

0.0614

0.1119

BMI (kg/m2)

0.4804

< 0.0001

0.5111

< 0.0001

Have chronic health conditionc

0.0680

0.0686

0.0001

0.9997

LF (msec2)

−0.0926

0.0055

−0.1260

0.0001

Black

0.0084

0.8050

0.0643

0.0560

Female

0.0549

0.0956

−0.0223

0.4973

Age (years)

−0.0391

0.2131

0.0006

0.9855

> HS

−0.0436

0.1767

−0.0685

0.0303

Current smoker

0.1219

0.0002

0.0769

0.0173

Ex-smoker

0.0245

0.4419

0.0139

0.6568

Physical activity score

−0.0290

0.3689

−0.0584

0.0683

SBP (mmHg)

−0.0267

0.4533

0.0435

0.2148

BMI (kg/m2)

0.5007

< 0.0001

0.5160

< 0.0001

Have chronic health condition

0.0525

0.1224

0.0023

0.9461

SD (msec)

−0.0723

0.0247

−0.0868

0.0065

Black

0.0153

0.6526

0.0761

0.0238

Female

0.0671

0.0387

−0.0036

0.9099

Age (years)

−0.0401

0.2058

0.0028

0.9301

> HS

−0.0459

0.1558

−0.0732

0.0211

Current smoker

0.1212

0.0003

0.0783

0.0160

Ex-smoker

0.0223

0.4832

0.0130

0.6817

Physical activity score

−0.0309

0.3403

−0.0608

0.0594

SBP (mmHg)

−0.0263

0.4603

0.0463

0.1883

BMI (kg/m2)

0.5074

< 0.0001

0.5257

< 0.0001

Have chronic health condition

0.0570

0.0940

0.0044

0.8952

HR (bpm)

0.0825

0.0108

0.0708

0.0276

Black

0.0185

0.5859

0.0796

0.0183

Female

0.0680

0.0356

0.0005

0.9882

Age (years)

−0.0234

0.4546

0.0219

0.4810

> HS

−0.0483

0.1339

−0.0762

0.0166

Current smoker

0.1160

0.0005

0.0775

0.0179

Ex-smoker

0.0233

0.4639

−0.0145

0.6460

Physical activity score

−0.0267

0.4103

−0.0585

0.0716

SBP (mmHg)

−0.0310

0.3863

0.0447

0.2074

BMI (kg/m2)

0.5042

< 0.0001

0.5239

< 0.0001

Have chronic health condition

−0.0531

0.1184

0.0014

0.9672

  1. acoeff: Standardized regression coefficients
  2. bHF power regressed on respiratory rate and residual used in analyses cSelf-reported hypertension or diabetes or cardioactive medication usage
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Molecular Medicine

ISSN: 1528-3658