Figure 2

Frequency of CD4⁺ and CD8⁺ mature T cells and recent thymic emigrants (RTE). Peripheral blood and spleen of F344 and F344.DA(Cia1) rats had decreased frequency of CD4⁺ mature T cells (A–B) and CD4⁺ RTEs (C–D). Cia5a accounted for the circulating levels of CD4⁺ T cells in blood (A) and spleen (B), and of CD4⁺ RTE in blood. Peripheral blood and spleen of F344 and F344.DA(Cia1) rats had increased frequency of CD8⁺ T cells (E–F) and RTE (G–H). Cia5a accounted for the difference in mature CD8⁺ T cells (E–F), but not RTE (G–H). Results are expressed as medians ± 25–75 percentiles for ACI (n = 9), DA (n = 9), F344 (n = 9), DA.F344(Cia5a) (n = 5), DA.F344(Cia5d) (n = 6) and F344.DA(Cia1) (n = 6) rats. All results were compared with DA. ^**P < 0.01; ^*P < 0.05; † P = .052; Mann-Whitney U test.