Figure 4

Frequency of CD45RC^lo T cells. The frequency of CD4⁺ CD45RC^lo T cells was increased in F344 and F344.DA(Cia1) in both peripheral blood (A) and spleen (B). Cia5a accounted for the difference of CD4⁺ CD45RC^lo T cells in peripheral blood (A). ACI rats had reduced frequency of CD4⁺ CD45RC^lo (A–B). CD8⁺ CD45RC^lo T cells were also increased in F344 peripheral blood (C), but not in spleen (D), which was not observed in F344.DA(Cia1) rats (C). Results are expressed as medians ± 25–75 percentiles for ACI (n = 10), DA (n = 10), F344 (n = 10), DA.F344(Cia5a) (n = 5), DA.F344(Cia5d) (n = 9) and F344.DA(Cia1) (n = 6) rats. Compared with DA: ^**P < 0.01, ^*P ≤ 0.05, †P= .058. Compared with F344: fP = .039. Mann-Whitney U test.