Figure 5

Frequency of CD25 cell surface expression within CD45RC^lo T cells. The frequency of CD4⁺ CD45RC^loCD25⁺ and CD8⁺ CD45RC^loCD25⁺ RTE and mature T cells in peripheral blood was similar in all strains (A–B). ACI rats had a higher percentage of CD25⁺ cells in splenic CD4⁺ CD45RC^lo mature T cells (C). The frequency of CD8⁺ CD45RC^loCD25⁺ splenic cells was increased in F344 rats, and Cia5d accounted for this difference (D). Results are expressed as medians ± 25–75 percentiles for ACI (n = 10), DA (n = 10), F344 (n = 10), and DA.F344(Cia5d) (n = 9) rats. All results were compared with DA. ^**P ≤ 0.01; ^*P ≤ 0.05; †P = .066; Mann-Whitney U test.