Table 1 Frequencies of different thymocyte maturation stages, recent thymic emigrants, and in vitro cytokine production by stimulated T cells from DA, F344, and ACI rats^a

Subset

Immunophenotype

DN2^b

CD3-CD90⁺

39.6 (37.7–46.8)

33.4 (29.9–37.9)

55.9 (51.2–56.5)^c

DN3 plus DN4^d

CD3⁺ CD90⁺ CD4⁻CD8⁻

0.8 (0.2–1.1)

0.8 (0.2–0.4)

0.5 (0.4–0.8)

DP^d

CD3⁺ CD90⁺ CD4⁺ CD8⁺

62.4 (40.7–81.7)

68.0 (47.0–83.3)

68.5 (40.7–79.2)

SP CD4^d

CD3⁺ CD90⁺ CD4⁺ CD8⁻

4.3 (2.9–6.3)

3.3 (2.3–4.7)

5.4 (3.3–7.3)

SP CD8^d

CD3⁺ CD90⁺ CD4⁻CD8⁺

29.0 (15.4–52.6)

28.9 (10.6–50.2)

25.6 (15.2–51.2)

RTE blood^e

CD3⁺ CD90⁺

32.8 (30.6–39.7)

33.3 (28.2–44.2)

36.1 (28.8–45.6)

RTE spleen^e

CD3⁺ CD90⁺

37.3 (33.5–41.6)

37.2 (25.3–43.3)

33.9 (27.3–37.1)

Cytokine ^f

concentration

Interferon-γ

ng/mL

46.3 (39–65)

54.4 (47–62)

48.56 (48–48)

IL-10

pg/mL

344 (183–601)

671 (363–908)

232.5 (167–354)

TNFα

pg/mL

311 (207–353)

236 (164–324)

352 (296–366)