Effect of reparixin on infarct volume 24 h after permanent MCAO in five different experiments. Results of individual experiments are expressed as the infarct volume in mm3 and are the mean ± S.D. The number of rats in each group is indicated in parenthesis. Reparixin (or saline) was administered with one of the following schedules: Experiments 1–3: 15 mg/kg i.v. at the time of MCAO followed by four 15 mg/kg s.c. doses at 2 h intervals; experiments 4–5: 15 mg/kg i.v. 1 h after MCAO, followed by three 15 mg/kg s.c.doses at 2 h intervals. Infarct volumes are determined 24 h after MCAO. Data meta-analysis was performed using Cochrane Collaboration’s Review Manager software (RevMan Version 4.2.9 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2003.). Experiment 1 is taken from ref (8).