Figure 3

Effects of ETP chemotherapy on leukocyte and platelet counts of the treated animals. Experimental animals were treated with various formulations of ETP. The blood samples of the treated animals were analyzed for their lymphocyte and platelet counts. (A) Free ETP significantly reduced the total leukocyte count (P < 0.001) compared with controls. Lip-ETP caused lesser myelosuppression compared with free ETP (P < 0.001). Tuft-Lip-ETP depleted fewer leucocytes compared with free ETP (P < 0.001) and Lip-ETP (P < 0.001). (B) A similar effect was observed on platelet counts as seen for total leukocyte count after treatment with free ETP (P < 0.001). The Lip-ETP group had significantly higher mean platelet counts (P < 0.001) than the free ETP group. The Tuft-Lip-ETP group had even higher platelet counts than the free (P < 0.001) and Lip-ETP (P < 0.001) groups. Data are means ± SD with n = 5 per group. ^aP < 0.001 versus free ETP; ^bP < 0.001 versus Lip-ETP.