Figure 5
(A) Effects of chemotherapy with various formulations of ETP on tumor development in Swiss mice. Treatment of tumor-bearing animals was started when the tumor size reached a volume of approximately 200 mm3. Free ETP and sham tuftsin liposomes significantly delayed tumor growth (P < 0.05) as compared with controls (PBS and Sham liposomes). Liposomal ETP was superior to free ETP in delaying tumor growth (P < 0.001). The regressions of tumors were recorded only in the group of animals treated with Tuft-Lip-ETP. Data are values ± SD (n = 20 at initiation of therapy, the number varies at later time points due to mortality). (B) Effects of ETP chemotherapy on the survival of tumor-bearing mice. The fibrosarcoma was induced by exposure to benzo (a) pyrene. The treatment of tumor-bearing animals was started at the time point when tumor size reached a volume of approximately 200 mm3. All the treated mice received a dose of 10 mg/kg body weight/day for 5 d with various formulations of the drug. Free ETP significantly enhanced the life span of the mice compared with the control group (PBS and sham liposomes) (P < 0.01). Lip-ETP was superior to free ETP in increasing the lifespan (P < 0.001). The best therapeutic effect was recorded in the group of animals treated with Tuft-Lip-ETP (P < 0.001). Data shown are the number of mice surviving at the given time points.