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Table 1 Jejunal tissue levels of antioxidant system elements [superoxide dismutase (SOD, catalase (CAT) and gluthatione peroxidase (GSH-Px)] and glutathione (GSH)] in sham-operated animals, vehicle-treated I/R animals, and I/R animals treated with EPO five minutes before ischemia and at the onset of reperfusion.

From: Erythropoietin Protects the Intestine Against Ischemia/Reperfusion Injury in Rats

  Enzymatic antioxidants Non-enzymatic antioxidant
  SOD (U/mg/protein) CAT (U/mg/protein) GSH-Px (U/mg/protein) GSH (umol/mg/protein)
Sham 4.94 ± 1.24 43.15 ± 4.7 0.036 ± 0.007 0.381 ± 0.079
I/R 6.18 ± 0.43 16.83 ± 2.6a 0.035 ±0.010 0.275 ±0.025
EPO + I/R 5.34 ± 0.66 42.85 ± 6b 0.034 ±0.013 0.262 ± 0.022
I + EPO + R 5.15 ± 0.88 29.31 ± 4.6 0.032 ± 0.008 0.280 ±0.028
  1. aP < 0.01 vs sham.
  2. bP < 0.01 vs vehicle-treated I/R animals.
  3. Data are mean ± S.E.M. (n = 5–7 per group). Note that there is a significant increase in the CAT levels in the EPO + I/R group compared with the I/R group. Sham; intestinal I/R was not induced, I/R; intestinal I/R, EPO + I/R; rHuEPO administered five minutes before ischemia, I + EPO + R; rHuEPO administered onset of reperfusion.