Figure 4

Functional networks of genes regulated by TPEN in THP-1 and Jurkat cells. The 86 genes whose expression was significantly altered by TPEN treatment in both THP-1 and Jurkat were analyzed with Ingenuity pathway analysis. Two networks with high significance were identified and merged. The resulting network is displayed, and the regulation of the genes is shown for Jurkat (A), THP-1 (B), and Raji (C). A network is a graphical representation of the molecular relationships between genes and gene products. Genes or gene products are represented as nodes, and the biological relationship between two nodes is represented as an edge (line). All edges are supported by at least one reference from the literature, from a textbook, or from canonical information stored in the Ingenuity Pathways Knowledge Base. The intensity of the node color indicates the degree of up- (red) or down- (green) regulation. Nodes are displayed using various shapes that represent the functional class of the gene product as indicated in the figure legend.