Figure 1

Experimental treatment of nude mice in six groups. The total experiment lasted for 6 wks. Group 1 was defined as the normal control. At the first and last 2 wks, the mice were given a basal diet. From the beginning of the third wk, the mice were treated with 0.2 mL corn oil every 2 d by oral gavage for 2 wks. Group 2 was the model group and mice were treated with IQ (50 mg/kg) dissolved in 0.2 mL corn oil for 2 wks. Groups 3–5 were treated with different doses of EGCG before and during the 2-wk treatment with the same dose of IQ as group 2. Doses of EGCG were 5, 10, and 20 mg/kg dissolved in 0.2 mL sterilized pure water every d. The group 6 EGCG control was treated with medium doses of EGCG (10 mg/kg) in the preceding 4 wks.