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Table 3 The Frequency (%) of Risk Alleles and Haplotype in Both Anti-CCP Positive and Negative RA Groups

From: Association of STAT4 with Rheumatoid Arthritis in the Korean Population

     P value
RiskaSNP/haplotype AntiCCP+ (n = 612) AntiCCP-(n = 111) Control CCP + vs. CCP-b CCP + vs. Controlc CCP- vs. Controld
rs11889341 35.2 34.5 29.7 0.84 0.001 0.14
rs7574865 38.8 38.6 32.9 0.96 0.001 0.11
rs8179673 38.9 40.0 34.0 0.77 0.005 0.08
rs10181656 38.9 40.0 34.2 0.76 0.007 0.09
Haplotype, TTCG 34.2 32.4 28.5 0.62 0.0009 0.23
  1. aOnly 723 cases with anti-CCP data were compared with a total of 1008 controls.
  2. bAll alleles and haplotype had statistically significant risk for anti-CCP positive RA compared with control [ORs (95% CI) 1.29 (1.11–1.50), 1.28 (1.10–1.51), 1.24 (1.07–1.43), 1.23 (1.06–1.42), and 1.29 (1.11–1.51) in order]
  3. cThe distribution of risk alleles and haplotype between antiCCP positive and negative groups were not significantly different.
  4. dP values of the risk alleles and haplotype in the anti-CCP negative group were not statistically significant level compared with control group.