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Table 3 The Frequency (%) of Risk Alleles and Haplotype in Both Anti-CCP Positive and Negative RA Groups

From: Association of STAT4 with Rheumatoid Arthritis in the Korean Population

    

P value

RiskaSNP/haplotype

AntiCCP+ (n = 612)

AntiCCP-(n = 111)

Control

CCP + vs. CCP-b

CCP + vs. Controlc

CCP- vs. Controld

rs11889341

35.2

34.5

29.7

0.84

0.001

0.14

rs7574865

38.8

38.6

32.9

0.96

0.001

0.11

rs8179673

38.9

40.0

34.0

0.77

0.005

0.08

rs10181656

38.9

40.0

34.2

0.76

0.007

0.09

Haplotype, TTCG

34.2

32.4

28.5

0.62

0.0009

0.23

  1. aOnly 723 cases with anti-CCP data were compared with a total of 1008 controls.
  2. bAll alleles and haplotype had statistically significant risk for anti-CCP positive RA compared with control [ORs (95% CI) 1.29 (1.11–1.50), 1.28 (1.10–1.51), 1.24 (1.07–1.43), 1.23 (1.06–1.42), and 1.29 (1.11–1.51) in order]
  3. cThe distribution of risk alleles and haplotype between antiCCP positive and negative groups were not significantly different.
  4. dP values of the risk alleles and haplotype in the anti-CCP negative group were not statistically significant level compared with control group.
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Molecular Medicine

ISSN: 1528-3658