Figure 6

Effect of Ang-(1-7), A-779, and genetic deletion of Mas on the thrombosis induced by 35% ferric chloride solution, in vivo. (A) Ang-(1-7) produced a dose-dependent inhibition of thrombus formation in C57Bl/6 mice with a maximal effect at 10 pmol/kg/min (**P < 0.01, *P < 0.05; one way ANOVA). (B) The antithrombotic effect of Ang-(1-7) was blocked by the Mas antagonist A-779 (**P < 0.01; one-way ANOVA). (C) The antithrombotic effect of Ang-(1-7) was abolished in Mas^−/− mice (*P < 0.05; one-way ANOVA). Each column represents the mean ± SEM from four to six experiments.