Table 2 Upregulated genes in CF PMNs compared with PMNs from healthy donors

Apoptose

XM_054989

Similar to caspase 8

2.11

0.004

U13699

Caspase 1

2.50

0.017

AL049703

PAC 179D3

1.54

0.023

AF310105

nalp1

1.65

0.034

Carbohydrate metabolism

X52486

Uracil-DNA glycosylase 2

1.87

0.002

Cell adhesion

X14787

Thrombospondin 1

1.73

0.035

X03168

Vitronectin

1.75

0.038

Cell cycle

D13639

Cyclin D2

1.51

0.001

D63878

Neural precursor cell expressed, develop

1.57

0.006

U18291

CDC16 (cell division cycle 16)

1.72

0.005

Chemokine

NM_002995

XCL1 (lymphotactin)

1.75

0.002

NM_003175

XCL2

1.52

0.004

NM_002416

CXCL9 (MIG)

1.84

0.004

BC010954

CXCL10 (IP10)

1.83

0.023

U16752

CXCL12 (SDF1)

1.91

0.012

D43767

CCL17 (TARC)

3.01

< 0.001

AF111198

CCL18 (PARC)

2.43

0.002

Cytokine and chemokine receptors

AB032734

CXCR2

2.89

< 0.001

M74782

IL-3 receptor α (low affinity)

5.35

0.001

U00672

IL-10 receptor α

4.08

< 0.001

U03187

IL-12 receptor β1

1.80

< 0.001

X03663

CSF-1 receptor

1.87

< 0.001

Cytoskeleton

X00351

β-Actin

1.85

0.003

DNA repair

L07541

Replication factor C (activator 1) 3 (38)

2.00

0.023

NM_005916

MCM7

1.62

< 0.001

Electron transport

M12792

Cytochrome P450, subfamily XXIA (steroid)

1.61

0.003

Growth factor

NM_000757

M-CSF

1.99

0.008

X03438

G-CSF (1)

3.20

<0.001

M13207

GM-CSF (1)

2.13

0.031

U66197

Fibroblast growth factor 12

2.08

<0.001

K03222

Transforming growth factor α

2.08

<0.001

M34309

Epidermal growth factor

2.22

0.038

M86528

Neurotrophin 5 (neurotrophin 4/5)

1.59

0.016

IFN-related

X57351

1-8D gene from IFN-inducible gene family

6.06

<0.001

X14454

IFN regulatory factor 1

1.83

<0.001

Metabolism

M64082

GAPDH

1.51

<0.001

M64082

Flavin containing monooxygenase 1

1.78

0.046

X14672

N-acetyltransferase 2 (arylamine N-acety)

1.95

0.016

Protein amino acid phosphorylation

U43522

Protein tyrosine kinase 2 beta

1.59

0.002

U24152

P21/Cdc42/Rac1-activated kinase 1 (yeast)

1.73

0.044

Protein folding

U07550

Heat shock 10-kDa protein 1 (chaperonin 10)

1.69

0.045

Receptor

M38690

CD9 antigen (p24)

1.92

0.008

Regulation of transcription

U35113

Metastasis associated 1

1.55

< 0.001

Sensory perception

L10035

Crystallin β B2

1.59

0.010

Signal transduction

AF074382

Ikk γ

2.48

0.001

AF241789

Ikk ε

2.60

0.001

X75208

EphB3

1.51

0.019

U07349

Mitogen-activating protein kinase kinase kinase kinase 2

1.93

0.026

U77129

Mitogen-activated protein kinase kinase kinase kinase 5

1.55

0.018

L05624

Mitogen-activated protein kinase kinase 2

1.69

0.018

U39657

Mitogen-activated protein kinase 6

2.17

0.015

D85815

ras homolog gene family

1.71

0.022

U81002

TRAF4

1.72

0.014

U18422

Transcription factor Dp-2

2.43

< 0.001

L23959

Transcription factor Dp-1

2.68

< 0.001

Transcription factor

L24804

v-myc

1.57

< 0.001

XM_113786

cfos

1.71

0.023

Transferase activity

U94352

Manic fringe (Drosophila) homolog

1.59

0.007

Ubiquitination

BC005980

Ubiquitin-conjugating enzyme E2D1

1.51

0.016

NM_003592

Cullin 1 (cdc53)

1.55

0.004

NM_004788

Ubiquitin factor E4A

1.78

0.007

NM_014248

Rbx-1

1.84

0.009