Table 3 Downregulated genes in CF PMNs compared with PMNs from healthy donors

Antigen presentation

M16276

MHC Class II HLA-DR2-Dw12

−1.51

0.001

cAMP biosynthesis

D14874

Adrenomedullin

−2.14

< 0.001

Cell cycle

U49089

Discs, large (Drosophila) homolog 3 (neu)

−2.14

<0.001

Chemokine

X78686

CXCL5 (ENA78)

−1.52

0.002

Y00787

CXCL8 (IL-8)

−2.19

0.003

Cytokine activity

A14844

IL-2

−1.79

0.016

NM_000576

IL-1 β

−1.67

0.001

Defense response

L08044

Intestinal trefoil factor

−1.62

0.001

DNA repair

M29971

O-6-methylguanine-DNA methyltransferase

−1.54

0.003

Growth factor

M27968

Fibroblast growth factor 2 (basic)

−1.69

0.001

M60828

Fibroblast growth factor 7

−1.57

0.014

IFN related

X01992

IFNγ

−1.71

0.012

Immune response

AB021288

β2-microglobulin

−1.92

0.004

Inflammatory response

M69043

MAD-3 (IK-B like activity)

−1.60

0.012

Ion transport

AF043233

H⁺/oligopeptide transporter

−1.95

0.017

Metabolism

X68060

Topoisomerase (DNA) II β (180 kDa)

−1.58

<0.001

Protein folding

U15590

Heat shock 27-kDa protein 3

−1.78

0.031

M86752

Stress-induced-phosphoprotein 1 (Hsp70/H)

−1.71

0.018

S67070

Heat shock 27-kDa protein 2

−1.62

0.003

Receptor

L24804

Inactive progesterone receptor, 23 kDa

−1.97

<0.001

Regulation of transcription

M83221

I-Rel

−1.55

0.034

U12767

MINOR

−1.55

< 0.001

Signal transduction

L25081

ras homolog gene family, member C

−1.72

0.001

X66360

PCTAIRE protein kinase 2

−1.68

< 0.001

Transcription factor

X16416

c-alb p150

−1.75

< 0.001

M95712

v-raf murine sarcoma viral oncogene homo

−1.52

< 0.001

Ubiquitination/degradation

BC002979

Proteasome α6

−1.67

<0.001