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Figure 3 | Molecular Medicine

Figure 3

From: Valproic Acid Sensitizes Chronic Lymphocytic Leukemia Cells to Apoptosis and Restores the Balance Between Pro- and Antiapoptotic Proteins

Figure 3

VPA-induced apoptosis is caspase dependent. (A) PBMCs from a representative CLL patient were cultured either in the presence or absence (−) of VPA (0.1, 0.5, 1, 2, 3 mM) for 3 days. Levels of caspases 8 and 9 were assessed from cellular lysates by Western blot. Equal loading of gels was documented with anti-actin antibody. Relative intensities of protein bands for p20 (activated caspase 8) (B) pro-caspase 8 (C), and pro-caspase 9 (D) were quantified with the TotalLab software and normalized to actin. Quantifications include data from at least 5 independent experiments.

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Molecular Medicine

ISSN: 1528-3658