Skip to main content
Figure 5 | Molecular Medicine

Figure 5

From: Valproic Acid Sensitizes Chronic Lymphocytic Leukemia Cells to Apoptosis and Restores the Balance Between Pro- and Antiapoptotic Proteins

Figure 5

VPA-mediated apoptosis in CLL cells involves both apical caspases. Primary CLL cells were cultured for 48 h in the presence or absence of 1, 2, or 3 mM VPA, the inhibitor solvent DMSO, caspase 8 inhibitor (c8), caspase 9 inhibitor (c9), or a combination of caspase inhibitors and 2 mM VPA. (A) Caspase 3 and 7 activities were analyzed and are presented relative to the untreated control (n = 5). (B) Western blot analysis of total cellular extracts was done for caspase 8 and 9 and BID; equal loading was ensured by reprobing with the actin antibody.

Back to article page

Molecular Medicine

ISSN: 1528-3658