Nonviral Vector Gene Modification of Stem Cells for Myocardial Repair

Table 7 Preclinical studies for nonvirally transfected cell-mediated gene delivery to the heart.

Vector	Type of cell	Target gene	Model	Species	Reference
Nonliposomal cationic (FuGene6)	Smooth muscle cells	Reporter gene (SEAP)	MI	Rat	56
Lipid base	SkM and heart cells	VEGF165	MI	Rat	52
Nonliposomal cationic (FuGene6)	Cardiac fibroblasts	SDF-1α	MI	Rat	53
Polyethylenimine Transferinfection	MSC	Heme oxygenase-1	MI	Rat	69
Lipofectamin Plus reperfusion	Smooth muscle cells	VEGF	Ischemia	Dog	70
Polyethylenimine	SkM	VEGF	MI	Pig	71

Ang-1, angiopoietin-1; FGF, fibroblast growth factor; HGF, hepatocyte growth factor; HIF, hypoxia inducible factor; PDGF, platelet-derived growth factor; SEAP, secreted alkaline phosphatase; VEGF, vascular endothelial growth factor.

ISSN: 1528-3658