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Table 9 Selected clinical studies of gene therapy using nonviral vectors in patients with ischemic diseases.

From: Nonviral Vector Gene Modification of Stem Cells for Myocardial Repair

Disease

Patient no.

Phase

Mode of delivery

Gene

Vector

Reference

CAD, restenosis

10

I

Catheter-based infusion after angiography

VEGF-A

Plasmid/liposome

72

CAD, in-stent stenosis

103

II/III

Catheter-based infusion after angiography

VEGF-A

Plasmid/liposome

73

CAD, in-stent stenosis

85

II

Catheter based infusion after angioplasty and stenting

c-myc antisense

Oligonucleotide

74

CAD

20

I

IM injection via minithorocotomy

VEGF-A

Naked plasmid

75

CAD

39

I

IM injection via minithorocotomy

VEGF-A

Naked plasmid

76

  1. CAD, coronary artery disease; IM, intramyocardial; VEGF-A, vascular endothelial growth factor-A.
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Molecular Medicine

ISSN: 1528-3658