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Table 1 Clinical and demographic characteristics of the study groups

From: Reduced Immune Complex Binding Capacity and Increased Complement Susceptibility of Red Cells from Children with Severe Malaria-Associated Anemia

 

Nyanza Provincial General Hospital (NPGH)

Kisii District Hospital (KDH)

 

Severe Anemia

Cerebral Malaria

Cerebral Malaria

Variable

Cases (N = 75)

Controls (N = 74)

P a

Cases (N = 8)

Controls (N = 15)

P

Cases (N = 24)

Controls (N = 37)

P

Mean age (SD) in months

16.9 (13.7)

16.8 (13.3)

NSb

35.9 (15.9)

35.7 (15.7)

NS

32.2 (20.4)

32.7 (16.8)

NS

No. Females (%)

34 (45.3)

33 (44.6)

NS

4 (50)

8 (53.3)

NS

12 (50)

19 (51.4)

NS

Mean Haemoglobin (SD) g/dL

4.7 (0.9)

8.7 (1.5)

NAc

8.6 (1.6)

9.1 (1.3)

0.45

9.2 (1.8)

9.6 (1.7)

0.45

%Corrected Reticulocyte (SD)d

1.5 (1.6)

1.4 (1.9)

NS

1.6 (1.6)

1.4 (1.4)

NS

1.5 (1.4)

1.5 (1.8)

NS

Mean # Parasites/µL × 10−3 (SD)

71.1 (27.1)

50.4 (32.1)

0.12

49.5 (46.8)

49.2 (24.6)

0.88

67.7 (76.4)

40.4 (60.9)

0.10

Home District (%)

         
 

Kisumu

30 (40.0)

38 (51.3)

4 (50)

6 (40)

0

0

   
 

Bondo

7 (9.3)

4 (5.4)

0

4 (26.7)

0

0

   
 

Nyando

15 (20.0)

5 (6.7)

0

2 (13.3)

0

0

   
 

Siaya

12 (16.0)

11 (14.9)

1 (12.5)

1 (6.7)

0

0

   
 

Vihiga

3 (4.0)

3 (4.1)

1 (12.5)

1 (6.7)

0

0

   
 

Rachuonyo

2 (2.7)

4 (5.4)

0

0

0

0

   
 

Kisii

0

0

0

0

6 (25)

10 (27.0)

   
 

Kisii Central

0

0

0

0

10 (41.7)

24 (64.9)

   
 

Gucha

0

0

0

0

3 (12.5)

2 (5.4)

   
 

Otherse

6 (8.0)

9 (12.2)

2 (25)

1 (6.7)

5 (20.8)

1 (2.7)

   

Ethnic group (%)

         
 

Luo

66 (88.0)

65 (87.8)

7 (87.5)

14 (93.3)

1 (4.2)

1 (2.7)

   
 

Luhya

6 (8.0)

9 (12.2)

1 (12.5)

1 (6.7)

2 (8.3)

0

   
 

Abagusii

0

0

0

0

21 (87.5)

36 (97.3)

   
 

Othersf

3 (4.0)

0

0

0

0

0

   
  1. aAll P values were obtained using paired t-test.
  2. bNS = Not Significant.
  3. cNA = Not applicable.
  4. dCorrected% reticulocyte was calculated as =% reticulocyte × (Subject Hct/Normal Hct) where normal Hct was 35% for age 0 to ≤ 6 months, 33% for age > 6 to ≤ 12 months, 30% for age > 12 to ≤ 24 months, 33% for age > 24 to ≤ 48 months, and 36% for age > 48 months.
  5. eOther Districts(N) = Budalangi(1), Bungoma(1), Busia(1), Butere-Mumias(2), Homa Bay(3), Kakamega(1), Meru(1), Migori(5), Nandi(2), Nyamira(4), South Nandi(1), Turkana(1), and Molo(1).
  6. fOther Ethnic Groups(N) = Kalenjin(1), Nandi(1), and Turkana(1).
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Molecular Medicine

ISSN: 1528-3658