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Table 1 Clinicopathological features and hypermethylation status of the 181 CRC patients included in the study.

From: p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer

  

p16

hypermethylation status

 

Parameter

All

negative

positive

P

Gender, n (%)

    

Female

80 (44.2)

52 (65.0)

28 (35.0)

 

Male

101 (55.8)

64 (63.4)

37 (36.6)

0.88a

Mean age (year ± SD)

69 ± 14

68 ± 14

72 ± 12

0.029b

Tumor location,d n (%)

    

Right-sided colon

62 (34.4)

37 (58.7)

26 (41.3)

 

Left-sided colon

47 (26.1)

34 (72.3)

13 (27.7)

 

Rectum

71 (39.5)

45 (63.4)

26 (36.6)

0.33c

Differentiation grade, n (%)

    

High/Moderate

119 (65.7)

79 (66.4)

40 (33.6)

 

Low

62 (34.3)

37 (59.7)

25 (40.3)

0.42a

Dukes’ tumor stage, n (%)

    

A

10 (5.5)

7 (70.0)

3 (30.0)

 

B

71 (39.2)

42 (59.2)

29 (40.8)

 

C

53 (29.3)

38 (71.7)

15 (28.3)

 

D

47 (26.0)

29 (61.7)

18 (38.3)

0.50c

Total, n (%)

181 (100)

116 (64.1)

65 (35.9)

 
  1. aP by Fisher’s exact test.
  2. bP by ANOVA t-test.
  3. cP by Pearson’s Chi-square test.
  4. dOne tumor was located at the borderline between the right and left side of the colon and could not be categorized with regard to tumor location.