Table 2 Cox multivariate analyses demonstrating the influence of p16 hypermethylation status in mucosa on cancer-specific survival and DFS of Dukes’ A–C, Dukes’ B, and Dukes’ C patients, respectively.

Hazard ratio^a (95% CI)^b

P ^c

Hazard ratio^a (95% CI)^b

P ^c

Hazard ratio^a (95% CI)^b

P ^c

Cancer-specific survival

No p16 hypermethylation

1

1

1

p16 hypermethylation

2.9 (1.3–6.2)

0.007

4.7 (1.1–19.5)

0.035

2.0 (0.67–5.9)

0.22

DFS

No p16 hypermethylation

1

1

1

p16 hypermethylation

2.5 (1.2–5.1)

0.015

3.2 (0.95–11)

0.060

1.8 (0.60–5.4)

0.30