Table 1 Genetics of early-onset Alzheimer’s disease.
From: Protein Aggregation in the Brain: The Molecular Basis for Alzheimer’s and Parkinson’s Diseases
Gene | Age of onset, years | Aβ phenotype |
|---|---|---|
APP trisomy 21 | 50s | Aβtotal production increased |
APP mutations | 50s | Aβtotal production increased |
Aβ42/Aβ40 ratio increased | ||
APP triplication of APP gene | 50s | Aβtotal production increased |
Presenilin 1 | 40s and 50s | Aβ42/Aβ40 ratio increased |
Presenilin 2 | 50s | Aβ42/Aβ40 ratio increased |