Figure 5

Effect of LPA on LPS-induced TNFα and IL-6 production in vitro in peritoneal macrophage. Peritoneal macrophages were incubated with LPS (10 µg/mL) with or without LPA (0.1–10 µM) for 18 h. LPS-induced TNFα (A) and IL-6 (B) production were examined by ELISA. Data represent means ± SE from three independent experiments. *, P < 0.05 compared with basal; #, P < 0.05 compared with LPS alone group.