Table 1 List of markers with χ² > 6.635 in 372 RA cases and 372 controls matched by DRB1 genotype. Odds ratios are shown assuming the risk allele is on the ancestral 8.1 haplotype (see Figure 2).

rs1341758

26308498

HIST1H2BF

0.962

0.93

6.99

0.0082

0.52

(0.32,0.83)

rs6913828

26354644

HIST1H4G

0.961

0.925

8.43

0.0037

0.5

(0.31,0.79)

rs3763338

29002291

RFP

0.935

0.891

8.6

0.0034

0.57

(0.39,0.82)

rs2071788

29020287

RFP

0.937

0.898

6.95

0.0084

0.59

(0.41,0.87)

rs6923005

29084051

ZNF311

0.77

0.7

8.98

0.0027

0.7

(0.55,0.88)

rs6930903

29089224

ZNF311

0.77

0.7

8.98

0.0027

0.7

(0.55,0.88)

rs6456889

29118804

OR2W1

0.78

0.719

6.93

0.0085

0.72

(0.57,0.92)

rs9295794

29212915

OR2J3

0.94

0.902

6.66

0.0098

0.59

(0.4,0.87)

rs9357078

29405646

OR5U1

0.923

0.88

7.21

0.0073

0.61

(0.43,0.87)

rs9380120

29443517

OR12D3

0.921

0.879

6.71

0.0096

0.63

(0.44,0.88)

rs2535315

31160107

C6orf15

0.58

0.648

7.11

0.0077

1.34

(1.09,1.66)

rs3778638

31200104

PSORS1C1

0.768

0.84

11.56

0.00067

1.58

(1.22,2.05)

rs3130453

31232829

CCHCR1

0.425

0.5

8.18

0.0042

1.35

(1.1,1.66)

rs1419881

31238573

TCF19

0.421

0.489

6.78

0.0092

1.32

(1.07,1.62)

rs887464

31253900

POU5F1

0.409

0.484

8.21

0.0042

1.36

(1.11,1.67)

rs3130531

31314596

HLA-C

0.575

0.653

9.15

0.0025

1.39

(1.13,1.72)

rs2844623

31340523

HLA-C

0.753

0.826

11.15

0.00084

1.56

(1.21,2)

rs2524077

31351583

HLA-C

0.783

0.863

15.55

8.10E-05

1.75

(1.33,2.29)

rs3130696

31351864

HLA-C

0.192

0.251

7.29

0.007

1.43

(1.11,1.84)

rs2524073

31352215

HLA-C

0.793

0.87

15.03

0.00011

1.75

(1.32,2.31)

rs2524044

31364733

HLA-C

0.762

0.824

8.29

0.004

1.47

(1.14,1.89)

rs3873385

31377288

HLA-C

0.77

0.832

8.6

0.0034

1.48

(1.15,1.92)

rs9264868

31379581

HLA-C

0.79

0.871

16.44

5.00E-05

1.79

(1.36,2.37)

rs9264869

31379610

HLA-C

0.793

0.87

15.03

0.00011

1.75

(1.32,2.31)

rs9264904

31380533

HLA-C

0.665

0.749

12.26

0.00046

1.51

(1.2,1.89)

rs1634747

31389856

HLA-C

0.402

0.485

10.04

0.0015

1.41

(1.14,1.73)

rs2596560

31463298

MICA

0.208

0.276

9.03

0.0027

1.46

(1.14,1.85)

rs3099844

31556956

HCP5

0.083

0.125

6.69

0.0097

1.6

(1.13,2.25)

rs2855812

31580700

MICB

0.226

0.289

7.44

0.0064

1.4

(1.1,1.77)

rs2857595

31676449

NCR3

0.124

0.183

9.44

0.0021

1.59

(1.19,2.12)

rs9267658

31953965

SLC44A4

0.876

0.919

6.86

0.0088

1.61

(1.14,2.27)

rs3134954

32179872

TNXB

0.872

0.918

7.8

0.0052

1.65

(1.17,2.33)

rs1035798

32259201

AGER

0.808

0.746

7.84

0.0051

0.7

(0.55,0.89)

rs394657

32295002

NOTCH4

0.342

0.417

8.47

0.0036

1.39

(1.12,1.72)

rs2857210

32849721

HLA-DQB2

0.682

0.767

13.28

0.00027

1.55

(1.23,1.96)

rs9276615

32851196

HLA-DQB2

0.686

0.769

12.44

0.00042

1.53

(1.21,1.93)

rs2621377

32871089

HLA-DOB

0.508

0.612

15.75

7.20E-05

1.56

(1.26,1.93)

rs2857151

32871493

HLA-DOB

0.55

0.661

18.63

1.60E-05

1.65

(1.33,2.05)

rs9276726

32871867

HLA-DOB

0.251

0.336

12.45

0.00042

1.52

(1.21,1.9)

rs1383261

32873430

HLA-DOB

0.255

0.341

12.74

0.00036

1.52

(1.22,1.91)

rs2621332

32888296

HLA-DOB

0.55

0.66

18.45

1.70E-05

1.65

(1.33,2.05)

rs2856997

32889755

HLA-DOB

0.618

0.526

12.28

0.00046

0.66

(0.53,0.82)

rs10484565

32903011

TAP2

0.934

0.862

20.39

6.30E-06

0.44

(0.31,0.63)

rs241433

32906774

TAP2

0.558

0.626

6.72

0.0096

1.33

(1.08,1.65)

rs2281389

33167775

HLA-DPB1

0.799

0.853

7.26

0.007

1.47

(1.12,1.92)

rs3117222

33168928

HLA-DPB1

0.74

0.798

6.83

0.0089

1.39

(1.09,1.77)

rs2064478

33180245

HLA-DPB1

0.757

0.817

7.76

0.0053

1.44

(1.12,1.85)

rs3117230

33183614

HLA-DPB1

0.757

0.817

7.59

0.0059

1.43

(1.11,1.84)

rs3117016

33203495

COL11A2

0.542

0.619

8.61

0.0033

1.38

(1.12,1.7)

rs3117004

33204745

COL11A2

0.603

0.682

9.81

0.0017

1.43

(1.15,1.77)

rs3130237

33205540

COL11A2

0.817

0.875

9.1

0.0026

1.57

(1.18,2.09)

rs6901221

33206255

COL11A2

0.818

0.877

9.52

0.002

1.59

(1.19,2.13)

rs986521

33244124

COL11A2

0.768

0.701

8.16

0.0043

0.71

(0.56,0.89)

rs2855430

33249259

COL11A2

0.836

0.899

11.83

0.00058

1.75

(1.28,2.39)

rs2855425

33252352

COL11A2

0.745

0.683

6.66

0.0099

0.74

(0.59,0.93)

rs2855459

33262635

COL11A2

0.835

0.891

9.55

0.002

1.63

(1.2,2.2)