Table 1 TLR4 polymorphisms and their impact.
From: Functional Consequences of Toll-like Receptor 4 Polymorphisms
Association | Stimulation | Transfection | Effect of polymorphism | |
|---|---|---|---|---|
Calvano et al. (57) | Systemic endotoxemia | Whole blood in vivo | No | |
Kumpf et al. (65) | Pre- and postoperative cytokines | Whole blood | No | |
In vivo and ex vivo response | Whole blood | No | ||
Newport et al. (62) | Pulmonary tuberculosis | Whole blood | No | |
Heesen et al. (66) | Cytokine synthesis | Whole blood | No | |
Von Aulock et al. (67) | LPS-induced cytokine release | Whole blood | No | |
Chang et al. (68) | TLR4 in peripheral neutrophils and monotypes | Whole blood | No | |
Marsik et al. (58) | Endotoxemia | Whole blood in vivo | Yes | |
Tiberio et al. (69) | Innate response to candidate adjuvants RC529 and monophosphoryl lipid A | Whole blood | No | |
Kroner et al. (70) | Multiple sclerosis | PBMCs | No | |
Van der Graaf et al. (71) | Stimulations with different TLR4 ligands | PBMCs | No | |
Peeters et al. (51) | Impact of polymorphisms on monocytes in patients with Crohn’s disease | PBMCs | No | |
Fagerås et al. (72) | Asthma | PBMCs | Yes | |
Erridge et al. (73) | LPS-induced monocytes signaling (monocytes) | PBMCs | Yes | |
Schmitt et al. (74) | Response to LPS | PBMCs | Yes | |
Norata et al. (75) | Intima-media thickness and LPS monocyte-derived macrophage response | PBMCs | No | |
Montes et al. (76) | Hematogeneous osteomyelitis | Neutrophils | Yes | |
Kinane et al. (77) | Porphyromonas gingivalis | Epithelial | Yes | |
Inhaled LPS | Airway epithelia | THP-1 | Yes | |
Arbour et al. (28) | Inhaled LPS | Airway epithelia | THP-1 | Yes |
Rallabhandi et al. (64) | Insights in stoichiometry, structure, and signaling | HEK-239T | Yes |