Skip to main content
Figure 2 | Molecular Medicine

Figure 2

From: 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis

Figure 2

(A) Overview of the experimental setting. Fibrosis was induced by the combination of TAA i.p. injections three times per wk and with an additional continuous supplement of EtOH (10% vol/vol) in the drinking water. At wk 24, Hepa129 HCC tumor cells were implanted into fibrotic mice livers and treated with VEGF-A siRNA with different formulations. (B and b) Representative paraffin sections of fibrotic liver samples with intrahepatic HCC satellites 11 d after implantation. Fibrosis was staged according to the score system proposed by Ishak et al. (16). Original magnification 40× (B), 100× (b).

Back to article page

Molecular Medicine

ISSN: 1528-3658