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Figure 3 | Molecular Medicine

Figure 3

From: 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis

Figure 3

(A and B) Representative proliferation marker (Ki-67) staining for determination of intratumoral proliferating cells 11 d after treatment initiation. Ki-67 staining showed significant differences between naked VEGF-A siRNA and DOTAP VEGF-A siRNA mice (A, VEGF-A siRNA; B, DOTAP VEGF-A siRNA, original magnification 64×). (C) Ki-67 statistical analysis for Ki-67-positive cells counted in HCC satellites. Satellite areas were measured before count with analyzing microscope software, and only Ki-67-positive cells were counted in size-matched satellites. Ki-67 count was significantly higher in HCC satellites obtained from mice that had been treated with naked VEGF-A siRNA compared with DOTAP VEGF-A siRNA.

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Molecular Medicine

ISSN: 1528-3658