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Figure 4 | Molecular Medicine

Figure 4

From: 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis

Figure 4

(A, a, and B) Representative images from mice treated either with fluoresceinlabeled naked siRNA without DOTAP formulation (A and a) or with DOTAP fluoresceinlabeled siRNA (B). Original magnification 100× (A/B), 200× (a). (C) Effect of DOTAP-formulated naked VEGF-A siRNA on hepatic VEGF expression. Gene silencing was significantly increased by the use of DOTAP VEGF-A siRNA compared with naked VEGF-A siRNA (P = 0.0014).

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Molecular Medicine

ISSN: 1528-3658