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Figure 6 | Molecular Medicine

Figure 6

From: 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis

Figure 6

(A) Naked VEGF-A siRNA sequence. Highlighted: immunostimulatory motifs as proposed by Judge et al. (23). The naked VEGF-A siRNA sequence contains a poly U motif on the siRNA antisense strain that is supposed to activate the immune system if formulated with DOTAP. (B and C) DOTAP VEGF-A siRNA effect on intrahepatic IFN-β (B) and TNF-α (C) expression after systemic i.p. administration of DOTAP-formulated VEGF-A siRNA and naked VEGF-A siRNA, respectively.

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Molecular Medicine

ISSN: 1528-3658