Figure 2

The effects of rosiglitazone (ROS) and of 15dPGJ2 in combination with adriamycin (0 nM to 250 nM) on PC-3 cell metabolism/growth, as assessed by MTT assay. (A) The effects of 15dPGJ2 (0 µM to 10 µM) and of ROS (0 µM to 10 µM) alone and in combination with 100 nM of adriamycin. Note the additive effect of adriamycin with PPARγ ligands on the metabolism/proliferation of PC-3 cell. (B) The effects of the increasing dose of adriamycin in combination with a standard dose of PPARγ ligands. Note that PPARγ ligands (2 µM of 15dPGJ2 and 5 µM of ROS) further increased the adriamycin-induced inhibition of PC-3 metabolism/growth, practically, at any concentration of adriamycin used in our experiments (0 nM to 250 nM).