Figure 3
From: Felodipine Reduces Cardiac Expression of IL-18 and Perivascular Fibrosis in Fructose-Fed Rats
Representative photographs of cardiac cross-sections stained immunohistochemically for IL-18. Sections were counterstained with hematoxylin to show nuclei in dark blue. A) IL-18 stain of cardiac tissue from control mouse. B) IL-18 stain of cardiac tissue from fructose-fed rat. C) IL-18 stain of cardiac tissue from fructose-fed rat treated with felodipine for 6 wks. D) Isotope IgG stain of cardiac tissue used as the primary antibody and as a control for comparison. Arrows indicate staining for IL-18. Bar = 50 µm. Bottom, results of quantitative image analysis for detection of IL-18 in the control (n= 12), fructose (n = 9), and felodipine (n = 9) groups. *P < 0.05, **P < 0.01 compared with the control group; §P < 0.05, §§P < 0.01 compared with the fructose group.