Table 1 Summary of the animal models used to assess the effects of estrogen on HSP expression. Species, strain, age, and length of time of E2 replacement following ovariectomy, as well as the reported change in HSP 72 expression are reported.
Species | Strain | Age | Ovxa to Study | HSP 72 | |
|---|---|---|---|---|---|
Bupha-Intr et al. 2004 (103) | Rat | SD | 8–9 weeks | 9 weeks | 20% decrease HSP 72 with ovx by Western |
Fekete et al. 2006 (98) | Rat | N/A | N/A | Intact | F > M post Ischemia/Reperfusion |
Nickerson et al. 2006 (102) | Rat | F344 | N/A | Intact | Female 0.46 versus male 0.4 pg/µg HSP 72 ELISA |
Papacontantinou et al. 2003 (94) | Mouse | N/A | N/A | 4 days SC E2 0.02mg/mL | Ovx 66% decrease |
Paroo et al. 2002 (101) | Rat | SD | N/A | Intact | Estrogen blocked exercise-associated increase HSP 72 |
Shinohara et al. 2004 (105) | Rat | SD | 10 weeks | 1 week | Ovx no effect HSP 72 |
Thawornkaiwong et al. 2007 (104) | Rat | SD | 8–9 weeks | 10 weeks SC E2 | Ovx 27% decrease in HSP 72 |
Voss et al. 2003 (95) | Rat | SD | 12–16 weeks | 9 weeks | Female 29 pg/µg at peak estrus versus male 14 pg/µg; ovx 9 weeks to male |