Table 1 Biological data.

SBP (mmHg)

148 ± 5

192 ± 4^b

143 ± 3

247 ± 3^b

193 ± 4^§

218 ± 16^b,c

F = 44.4

F = 381.1

F = 63.1

P < 0.0001

P < 0.0001

P < 0.0001

Body Weight

262 ± 3

256^b ± 5

276 ± 3

210 ± 6^b

215 ± 6^b

244 ± 4^b,c

F = 12

F = 66

F = 44

(BW, g)

P < 0.001

P < 0.0001

P = 0.003

Heart Weight

808 ± 12

876 ± 14

816 ± 11

812 ± 20

705 ± 25

948 ± 48

F = 3.3 ns

F = 4.3

F = 5.1

(HW, mg)

P < 0.05

P < 0.05

HW/BW index

3.08 ± 0.13

3.44 ± 0.24

2.95 ± 0.18

3.88 ± 0.35^d

3.3 ± 0.1

3.9 ± 0.3^d

F = 9.1

F = 156

F = 31

P < 0.01

P < 0.001

P < 0.001

Aortic wet weight

63.4 ± 1.8

73.8 ± 3.8

71.1 ± 2.6

97.9 ± 2.9^b

70.3 ± 2.3^c

89 ± 4^b

F = 29.9

F = 40.6

F = 8

(mg)

P < 0.0001

P < 0.0001

P = 0.006

Secreted proteins

0.63 ± 0.03

0.64 ± 0.02

0.58 ± 0.02

1.02 ± 0.04^b

0.56 ± 0.02^c

0.75 ± 0.05^b,c

F = 23.4

F = 45.6

F = 40.3

(µg/mL)

P < 0.0001

P < 0.0001

P < 0.0001

Secreted PAI-1

1.2 ± 0.1

1.4 ± 0.1

1 ± 0.1

2.1 ± 0.3^b

1.1 ± 0.1^c

1.4 ± 0.1^c

F = 1.32

F = 8.3

F = 4.4

(ng/mg tissue)

P= 0.3

P= 0.09

P < 0.04

Plasma PAI-1

0.36 ± 0.13

0.68 ± 0.28

0.14 ± 0.06

1.24 ± 0.1^b

0.47 ± 0.05^c

0.8 ± 0.1^b,c

F = 0.066

F = 12.4

F = 3.8

(ng/mL)

P = 0.42

P = 0.002

P = 0.06