Proteomic Analysis Permits the Identification of New Biomarkers of Arterial Wall Remodeling in Hypertension

Table 2 Description of all identified biomarkers.

m/z ^a	Calc. MW	P value^b	Higher in	Calc. pI	Protein name	Modifications
4962	4963.46	0.008	FLN > F^c, BN, BNLN	5.02	Thymosin β-4	N-term. Ser acetylated
5169	5169.66	0.008	FLN > F^c, BN, BNLN		Thymosin β-4, SPA adduct
7286	7280.25	0.002	F > FLN^c	7.2	Copper transport protein ATOX1	Cystenylated?
8564	8564.84	0.001	FLN > F^c, BN, BNLN	6.56	Ubiquitin
9940	9938.27	0.001	BNLN > FLN^c	8.78	Acyl-CoA-binding protein (Endozepine)	N-term. Ser acetylated
10704	10703.41	0.001	FLN > F^c, BN, BNLN	9.18	Rat protein gi/34881882, C-terminal fragment	C-terminal fragment
11472	11 469.71	0.01	F > FLN^c	4.15	Parathymosin	N-term. Ser acetylated
12133	12 130.90	0.001	BNLN > FLN^c	9.61	Cytochrome C	N-term. Gly acetylated, heme c
13721	13 717.19	0.02	F > FLN^c	5.77	Transthyretin	Cysteinylated?
15201	15 197.34	0.006	FLN > F^c, BN, BNLN	7.93	Hemoglobin α chain
18927		0.006	FLN > F^c, BN, BNLN		Transgelin (smooth muscle protein 22-alpha)	C-terminal truncation
20140	20 135.98	0.001	FLN > F, BN, BNLN	7.07	Transgelin (smooth muscle protein 22-alpha)	C-terminal truncation
22460	22 513.66	0.001	FLN > BNLN^c F, BN	8.88	Transgelin (smooth muscle protein 22-alpha)	N-term. Ala acetylated
51580	51 782.26	0.02	BNLN > FLN F, BN	5.41	Vitamin D binding protein

^aThis table summarizes for all identified m/z values both observed and calculated.
^bThe P value determined between the different groups of rats (F: Fischer Control, FLN: Fischer L-NAME, BN: Brown Norway Control, BNLN: Brown Norway L-NAME).
^cGroups which have been compared to determine the P value.

ISSN: 1528-3658