Figure 2

Clinical course of psychopathology ratings before and during treatment with the cyclooxygenase inhibitor celecoxib. The course of the Hamilton Depression Rating Scale (HAM-D) scores, the Young Mania Rating Scale (YMRS) scores, and the Positive and Negative Syndrome Scale (PANSS) scores, presented in line graphs, show a pronounced cycling pattern. Day 0 denotes start of celecoxib intake. The magnitude of cyclic changes appears to gradually decrease during treatment. Bar graphs give scores (mean ± SEM) of n = 6 depressed and n = 6 manic episodes (two before and four after onset of treatment each). HAM-D score in depressed and YMRS score in manic episodes decrease significantly upon treatment. Mean values are compared using independent Student t test (two-tailed). M = manic episode, D = depressed episode.