Table 1 Psychopathology, physical signs and neuropsychological test results (before celecoxib).

Psychopathology

Mood

dysphoric, despair, anxiety

expansive, exuberant, irritable

Drive

impaired:

increased:

- most of the time in bed

- seeking contacts

- social withdrawal

- loss of inhibition

- neglected personal hygiene

- unnecessary purchases

- reduced self-care

- booking of travels

Thought process

brooding, difficulty making decisions, slowed thinking

logorrhea, distractibility, poor concentration, racing thoughts

Suicidality Gestures and mimic

passive death wishes mask-like face and slow limb movements oculomotoric decreased sad appearing withdrawn

joie de vivre (“Lebensfreude”) rich in gestures and facial expression oculomotoric increased searching for eye contact and attention

Voice

low pitched, monotonous

high pitched, melodious

Handwriting

jittery and slow

orthographic mistakes and corrections

Dotting

moderately impaired

normal

Tapping

moderately impaired

moderately impaired

HAM-D^a

range between 31 and 38

range between 3 and 4

BDI^b

range between 44 and 52

range between 3 and 5

YMRS^c

range between 1 and 3

range between 21 and 24

PANSS^d

range between 84 and 92

range between 40 and 41

Autonomic and physical signs

Sleep

increased requirement for sleep and daytime in bed

reduced requirement for sleep and disrupted sleep

Appetite

decreased

increased

Weight

decreased

increased

Libido

absent

increased

Allergy

no allergies

susceptibility to allergies

Edema

no edema

edema on lower extremities

Neuropsychology

Short-term memory

mildly impaired

mildly impaired

Long-term memory

normal

normal

Working memory

moderately impaired

severely impaired

Semantic fluency

moderately impaired

normal

Executive functions

moderately impaired

severely impaired

Psychomotor speed

moderately impaired

moderately impaired