Table 3 Non-Immune Genes Associated with Malignancy

Increased Expression

Angiogenesis

Fibroblast growth factor bp 1

FGFBP1

NM_005130

5.3

↑

Phosphoglycerate kinase 1

PGK1

S81916

4.5

↑

Placental growth factor

PGF

BC001422

3.1

↑/↓

Vascular endothelial growth factor

VEGFA

AF022375

4.8

↑

Hypoxia-induced

Carbonic anhydrase II

CAII

M36532

8.3

↑

Carbonic anhydrase XII

CAXII

BC000278

4.0

↑

Hypoxia-inducible factor 1_

HIF1A

NM_001530

3.1

↑

Hypoxia-inducible protein 2

HIG2

NM_013332

5.5

↑/↓

Growth, Differentiation and Apoptosis

Cyclin-dependent kinase inhibitor 1A

CDKN1A

NM_000389

3.7

↓

Inhibitor of DNA binding 1

ID1

D13889

5.4

↑

Inhibitor of DNA binding 2

ID2

NM_002166

3.1

↑

Insulin-like growth factor bp 3

IGFBP3

BF340228

3.4

↑/↓

Parathyroid hormone-like hormone

PTHLH

BC005961

9.3

↑

TP53 apoptosis effector

PERP

NM_022121

5.8

↑

Membrane, Adhesion and Extracellular Matrix-Associated

Calcium chloride channel activated 2

CLCA2

NM_006536

4.4

↑/↓

Fascin 1

FSCN1

NM_003088

4.2

↑

Kallikrein-related peptidase 12

KLK12

NM_019598

4.5

↑

Lectin, galactoside-binding, soluble, 7

LGALS7

NM_002307

7.7

↑

Plakophilin 1

PKP1

AI378979

5.4

↓

Enzymes and Enzyme Inhibitors

Aldo-keto reductase family 1 B10

AKR1B10

NM_020299

3.6

↑

Cathepsin L2

CTSL2

AF070448

3.7

↑

Serine Protease Inhibitor B3

SERPINB3

AB046400

4.8

↑

Serine Protease Inhibitor B4

SERPINB4

U19557

3.3

↑

Serine Protease Inhibitor B13

SERPINB13

AF169949

4.1

↑

Decreased Expression

Extracellular Matrix Associated

Dermatopontin

DPT

AI146848

−6.8

↑

Mucin 5AC

MUC5AC

AW192795

−11.7

↓

Tenascin XB

TNXB

M25813

−5.8

↓

Tumor Suppressors

Apolipoprotein D

APOD

NM_001647

−4.1

↓

Four and a half LIM domains 1

FHL1

NM_001449

−3.7

↓

Insulin-like growth factor bp 5

IGFBP5

L27560

−4.0

↓

SPARC-like 1 (mast9, hevin)

SPARCL1

NM_004684

−3.7

↓

Other

Apolipoprotein J

APOJ

AI982754

−7.0

↓

Glutathione S-transferase A2

GSTA2

NM_000846

−5.6

↑