Table 2 Antigenic reactivities of CLL mAbs
Reactivity with | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
CLL mAb | Subse†a | IGHV gene | Mutation statusa | Healthy HEp-2 cellsb | Apoptotic RAMOS B cellsc | Apoptotic Jurkat T cellsc | MDA-BSAd | POVPC-BSAd | HNE-BSAd | PC-BSAd | Oxidized LDLd |
068 | 6 | 1–69 | U-CLL | + | + | + | + | ++ | |||
258 | 6 | 1–69 | U-CLL | + | − | − | + | − | − | + | − |
014 | 9 | 1–69 | U-CLL | + + + | ++++ | +++ | + | + | − | + | − |
246 | 9 | 1–69 | U-CLL | + | +++ | ++ | + | − | − | + | − |
355 | 9 | 1–69 | U-CLL | + + + | ++++ | ++ | + | − | − | − | − |
358 | NA | 1–69 | M-CLL | + | − | − | − | − | − | − | − |
154 | 1 | 1–18 | M-CLL | + | + | + | + | − | − | − | − |
340 | 1 | 1–2 | U-CLL | + | + | + | ++ | − | − | + | − |
360 | 1 | 1–3 | U-CLL | ++ | ++ | + | ++ | − | − | + | − |
270 | 1 | 1–2 | U-CLL | + | + | + | ++++ | − | − | + | + |
DO13 | 28 | 1–2 | U-CLL | ++ | +++ | + | ++++ | + | + | ++ | ++ |
376 | NA | 1–24 | U-CLL | + | − | − | − | − | − | − | − |
415 | NA | 1–3 | U-CLL | + | + | + | + | − | − | + | − |
366 | 9 | 3–21 | U-CLL | + | ++ | + | ++ | + | − | + | + |
282 | 2 | 3–21 | M-CLL | + | − | − | − | − | − | − | − |
412 | 2 | 3–21 | M-CLL | + | − | − | − | − | − | − | − |
562 | NA | 3–21 | U-CLL | + | − | − | − | − | − | − | − |
169 | NA | 3–33 | M-CLL | + | − | − | − | − | − | − | − |
141 | NA | 4–34 | U-CLL | + | + | + | − | − | − | − | − |
DO8 | NA | 4–34 | U-CLL | + | + | + | + | + | − | + | − |
183 | 4 | 4–34 | M-CLL | + | − | − | − | − | − | − | − |
240 | 4 | 4–34 | M-CLL | + | − | − | − | − | − | − | − |
342 | 4 | 4–34 | M-CLL | + | + | + | + | − | − | − | + |
114 | 8 | 4–39 | U-CLL | ++++ | + | + | +++ | + | − | + | + |
657 | 8 | 4–39 | U-CLL | ++++ | ++ | ++ | ++++ | + | − | + | ++ |
845 | 8 | 4–39 | U-CLL | ++++ | + | + | +++ | + | − | ++ | + |
260 | NA | 4–b | U-CLL | + | + | ++ | + | − | − | + | − |
255 | NA | 4–59 | M-CLL | ++ | − | − | + | + | − | − | − |