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Figure 4 | Molecular Medicine

Figure 4

From: Surface Expression of Bcl-2 in Chronic Lymphocytic Leukemia and Other B-Cell Leukemias and Lymphomas Without a Breakpoint t(14;18)

Figure 4

Correlation between smBcl-2 expression and induction of apoptosis. (A) Analysis of fresh cells. B-cells from B-CLL patients and age-matched normal controls, that were never frozen, were analyzed simultaneously for smBcl-2 expression (left bar) and for apoptosis (n = 12). PI was used to quantify apoptosis by DNA fragmentation (middle bar) (n = 6) as well as Annexin V positivity (right bar) (n = 6). Asterisk indicates a significant difference in levels of smBcl-2 between normal and B-CLL samples (P = 0.02). (B) Heat-challenged normal B cells. Normal B cells from normal age-matched subjects were exposed to a 60° C hot water bath and then analyzed for smBcl-2 and viability by Annexin V binding; levels are shown before heating (left) and after (right), respectively.

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Molecular Medicine

ISSN: 1528-3658