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Figure 5 | Molecular Medicine

Figure 5

From: Surface Expression of Bcl-2 in Chronic Lymphocytic Leukemia and Other B-Cell Leukemias and Lymphomas Without a Breakpoint t(14;18)

Figure 5

Levels of smBcl-2 after chemical induction of apoptosis. (A) Apoptosis induction by camptothecin. Graphic representation of the differences in levels of apoptosis (white bar) and smBcl-2 (gray bar) after camptothecin treatment. Cells from normal, age-matched (AG) control B cells (left) and B-CLL patients (right) were exposed to 10 MM camptothecin for 1 d and then analyzed for smBcl-2 and apoptosis. Apoptosis was induced significantly in both groups. The change in smBcl-2 was significant only for B-CLL cells (P = 0.03). (B) Annexin and smBcl-2 co-expression on CLL cells. Histogram of a representative B-CLL sample gated on cells with high (left) or low (right) levels of Annexin V binding.

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Molecular Medicine

ISSN: 1528-3658