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Table 1 Nicotine dependence genes.a

From: Genome-Wide Association for Nicotine Dependence and Smoking Cessation Success in NIH Research Volunteers

    

Clustered SNPs

     

MNB

 

Gene

Gene description

Chromosome

Base pair

Hamer

I

II

Bierut

A2BP1

Ataxin 2-binding protein 1

16

6009133

6

3

 

13

C10orf11

Chromosome 10 open reading frame 11

10

77212525

9

 

3

1

CAPN13

Calpain 13

2

30799141

4

3

 

2

CDH13

Cadherin 13

16

81218079

14

6

3

2

CHL1

Close homolog of L1

3

213650

2

7

 

3

CNTN6

Contactin 6

3

1109629

9

4

 

6

CSMD1

CUB and Sushi multiple domains 1

8

2782789

14

15

10

12

CSMD2

CUB and Sushi multiple domains 2

1

33752196

5

4

  

CSRP3

Cysteine and glycine-rich protein 3

11

19160154

3

 

3

 

CTNNA3

Catenin α 3

10

67349937

4

4

3

21

CTNND2

Catenin delta 2

5

11024952

4

3

 

1

CXCL14

Chemokine (C-X-C motif) ligand 14

5

134934274

2

 

4

 

DDEF1

Development and differentiation enhancing factor 1

8

131133535

4

3

  

FHIT

Fragile histidine triad gene

3

59710076

15

3

5

2

FHOD3

Formin homology 2 domain containing 3

18

32131700

8

 

3

 

FLJ45872

FLJ45872 protein

8

138890869

4

3

  

GRIK2

Glutamate receptor, ionotropic, kainate 2

6

101953675

4

 

3

1

GRM3

Glutamate receptor, metabotropic 3

7

86111166

4

3

 

1

HPSE2

Heparanase 2

10

100208867

9

3

 

1

LRP1B

Low density lipoprotein-related protein 1B

2

140705466

4

5

 

4

LRRN6C

Leucine rich repeat neuronal 6C

9

27938528

7

4

 

18

NME7

Nucleoside-diphosphate kinase

1

167368393

4

 

14

 

PARD3B

Par-3 partitioning defective 3 homolog B

2

205118761

4

3

  

PBX1

Pre-B-cell leukemia transcription factor 1

1

95561

4

 

5

 

PDE1C

Phosphodiesterase 1C

7

31795772

9

3

3

 

PTPRM

Receptor type protein tyrosine phosphatase M

18

7557817

5

3

  

RAD51L1

RAD51-like 1

14

67356262

5

 

3

 

RYR3

Ryanodine receptor 3

15

31390469

5

5

 

3

SGCZ

Sarcoglycan zeta

8

13991744

6

7

  

THSD4

Thrombospondin type I dom 4

15

69220842

4

_

3

 
  1. aGenes that contain overlapping clusters of nominally positive SNPs in comparisons of nicotine-dependent individuals versus individuals who report use of <100 cigarettes in their lives (Hamer samples) as well as Liu/Drgon et al. and/or Beirut et al. comparisons. Columns list gene description, chromosome, base pairs for gene’s start, number of nominally positive SNPs that lay in clusters within the gene’s exons and in 10-kb genomic flanking regions, and the numbers of clustered, nominally positive SNPs that fall within overlapping clusters within the same gene from Liu/Drgon et al. The 600k (MNB I) and 1M (MNB II) data from the National Institute on Drug Abuse research volunteers dependent on at least one illegal substance and from the Bierut et al. 38k dataset (15) are listed in the last three columns. All of the genes that are identified by clustered nominally positive data from the current dataset are presented in Table S1.
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Molecular Medicine

ISSN: 1528-3658