Figure 4
From: Macrophage Migration Inhibitory Factor Promotes Colorectal Cancer
Recombinant MIF (rMIF) treatment increases the mRNA expression of several genes known to be upregulated in cancerous tissue. In particular, two isoforms of VEGF (165 and 121; lanes 1 and 2) and metalloproteinase-9 (lanes 5 and 6), but not metalloproteinase-2 (lanes 3 and 4), were upregulated in LoVo colorectal cells treated with rMIF (250 ng/mL, 24 h; even-numbered lanes) relative to parallel vehicle treatment (odd-numbered lanes).