Table 1 Comparison of the non-ADAPT and ADAPT subpopulations.a
From: High Serum Aβ and Vascular Risk Factors in First-Degree Relatives of Alzheimer’s Disease Patients
Non-ADAPT subjects (n = 98) | ADAPT subpopulation subjects (n = 197) | P-value | |
|---|---|---|---|
n (%) | |||
Female (%) | 54 (55) | 91 (47) | 0.17 |
White (%) | 96 (98) | 193 (98) | 0.68 |
Diabetes (%) | 8 (8) | 19 (10) | 0.74 |
Hypertension (%) | 55 (57) | 122 (62) | 0.39 |
Hypercholesterolemia (%) | 38 (39) | 103 (52) | 0.03 |
APOE ε4 allele (%) | 27 (28) | 63 (32) | 0.44 |
Mean ± SD | |||
Age (years) | 75.2 ± 8.21 | 76.8 ±3.93 | 0.07 |
Serum Aβ1–40 (pg/mL)b | 132.6 ±49.65 | 146.3 ±54.59 | 0.13 |
Median [IQR] | |||
Serum Aβ1–42 (pg/mL) | 4.9 [2.9,9.1] | 12.0 [5.0,22.9] | P < 0.001 |
Serum Aβ1–42/Aβ1–40 | 0.04 [0.02,0.07] | 0.08 [0.05,0.15] | P < 0.001 |