Figure 5

Pathways and networks associated with HSPA9, PHB, and ABCB6. Pathway Studio software was used to map the above three identified proteins onto characterized human pathways and networks that are associated with these proteins based on known protein-to-protein interactions, mRNA expression studies, and other biochemical interactions previously described. Proteins belonging to different structural and functional families had PHB as a common target and were involved in processes such as mitogenesis, defense response, germination, inflammation, proliferation, and apoptosis. Most of the diseases associated with these three proteins were cancer derived from various organs.