Table 2 Human homologues of murine Nrf2-modulated genes highly smoking-responsive in the human small airway epithelium.^a

Adh7

Alcohol dehydrogenase 7

ADH7

5.7

P < 4 × 10⁻¹⁶

(19,23)

Fgrp, Fr-1

Aldo-keto reductase family 1, member B10

AKR1B10

23.5

P < 2 × 10⁻⁸

(23)

Aldh3a1

Aldehyde dehydrogenase 3 family, memberA1

ALDH3A1

4.8

P < 6 × 10⁻¹⁵

(19,71)

G6pdx

Glucose-6-phosphate dehydrogenase

G6PD

1.9

P < 6 × 10⁻⁶

(19,23,71)

Gclc

Glutamate-cysteine ligase, catalytic subunit

GCLC

1.6

P < 2 × 10⁻⁴

(16,18,19,22–24,26)

Gpx2

Glutathione peroxidase 2

GPX2

6.4

P < 2 × 10⁻¹²

(10,17,18,23,25,26)

Gsr

Glutathione reductase

GSR

1.6

P < 1 × 10⁻⁶

(10,23,24)

Mdh-1,Mod-1

Malic enzyme 1, NADP(+)-dependent, cytosolic

ME1

3.8

P < 2 × 10⁻¹⁴

(10,19,23,26)

Nqo1

NAD(P)H dehydrogenase, quinone 1

NQO1

2.4

P < 2 × 10⁻¹⁴

(10,16–21,23,41)

Pgd

Phosphogluconate dehydrogenase

PGD

1.6

P < 8 × 10⁻⁶

(23)

Tkt, P68

Transketolase (Wernicke-Korsakoff syndrome)

TKT

1.8

P < 3 × 10⁻⁸

(19)

Txnrd1

Thioredoxin reductase 1

TXNRD1

1.9

P < 6 × 10⁻¹¹

(18,19,22,23,26)

Ugt1-06

UDP glucuronosyltransferase 1 family, polypeptide A6

UGT1A6

2.0

P < 3 × 10⁻⁷

(16–19)