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Table 3 Comparison of demographics of healthy smokers with different ranges of the Nrf2 index.a

From: Coordinate Control of Expression of Nrf2-Modulated Genes in the Human Small Airway Epithelium Is Highly Responsive to Cigarette Smoking

Parameter

Ranges of Nrf2 indexb

1–2

2–3

3–4

P valuec

n

13

17

15

 

Age, years

40 ± 2

42 ± 1

46 ± 2

P > 0.2

Sex, male/female

7/6

11/6

14/1

P > 0.8

Ancestry, B/W/H/A/O

7/2/4/0/0

12/4/1/0/0

9/5/1/0/0

P > 0.2

Smoking history, pack-year

22 ± 3

27 ± 4

32 ± 5

P > 0.4

Urine nicotine, ng/mL

1205 ± 412

801 ± 217

935 ± 212

P > 0.2

Urine cotinine, ng/mL

894 ± 206

913 ± 192

1367 ± 212

P > 0.3

Venous carboxyhemoglobin, %

1.6 ± 0.4

1.8 ± 0.6

2.0 ± 0.3

P > 0.1

  1. aData are presented as mean ± standard error.
  2. b1–2 = low expression of Nrf2-modulated genes; 2–3 = moderate expression level of Nrf2-modulated genes; 3–4 = high expression of Nrf2-modulated genes.
  3. cGroup comparison with ANOVA or chi-square test.
  4. dB, black; W, white; H, Hispanic; A, Asian; O, other.
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Molecular Medicine

ISSN: 1528-3658