Coordinate Control of Expression of Nrf2-Modulated Genes in the Human Small Airway Epithelium Is Highly Responsive to Cigarette Smoking

Hübner, Ralf-Harto; Schwartz, Jamie D.; De, Bishnu P.; Ferris, Barbara; Omberg, Larsson; Mezey, Jason G.; Hackett, Neil R.; Crystal, Ronald G.

doi:10.2119/molmed.2008.00130

Molecular Medicine

Table 4 Identification of genes not previously associated with Nrf-2 control identified by the correlation of the Nrf2 index with the level of expression of all genes in the small airway epithelium of healthy smokers.^a

From: Coordinate Control of Expression of Nrf2-Modulated Genes in the Human Small Airway Epithelium Is Highly Responsive to Cigarette Smoking

Probe set ID^b	Gene symbol	Gene title	r ²	Location of ARE, bp^c	References
201463_s_at	TALDO1	Transaldolase 1	0.81	−5578	(10,40)
205623_at	ALDH3A1	Aldehyde dehydrogenase 3 family, memberA1	0.79	−7761	(23)
201467_s_at	NQO1	NAD(P)H dehydrogenase, quinone 1	0.79	−8447, −386	(16–21,41)
201266_at	TXNRD1	Thioredoxin reductase 1	0.77	−9409, −4225, −20, 20179, 21409, 21979, 2809	(18,19,22,23,26)
207469_s_at	PIR	Pirin	0.76	−5466, −3480, −3209, 33	None
204059_s_at	ME1	Malic enzyme 1, NADP(+)-dependent, cytosolic	0.76	−7400, −2164, −129	(10,23,26,37)
210519_s_at	NQO1	NAD(P)H dehydrogenase, quinone 1	0.74	−8447, −386	(10,16–23,41)
211653_x_at	AKR1C2	Aldo-keto reductase family 1, member C2	0.74	−8778, −6724, −5404, −2803, −1689, −1655	(42)
202831_at	GPX2	Glutathione peroxidase 2	0.73	−6897, −5842, −3600, −55	(10,17,23,25,26,37)
208700_s_at	TKT	Transketolase	0.70	−7278, −6731, −5713, −1261	(19)
203192_at	ABCB6	ATP-binding cassette, sub-family B, member 6	0.69	−7575	None
209699_x_at	AKR1C2	Aldo-keto reductase family 1, member C2	0.67	−8778, −6724, −5404, −2803, −1689, −1655	(42)
204532_x_at	UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	0.66	−5523, −3885, −3159, −3043	None
215125_s_at	UGT1A1-10	UDP glucuronosyltransferase 1 family, polypeptide A1-10 ⁴	0.66	No unique gene^d
207126_x_at	UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	0.65	−5523, −3885, −3159, −3043	None
206094_x_at	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	0.65	−7826	(16–19,43)
209160_at	AKR1C3	Aldo-keto reductase family 1, member C3	0.65	No ARE^e
216594_x_at	AKR1C1	Aldo-keto reductase family 1, member C1	0.65	−9655, −6191, −4718, −3583, −1717	(42)
203925_at	GCLM	Glutamate-cysteine ligase, modifier subunit	0.63	−9	(10,19,23,25)
204151_x_at	AKR1C1	Aldo-keto reductase family 1, member C1	0.63	−9655, −6191, −4718, −3583, −1717	(42)
1555854_at	—	Transcribed locus	0.61	Not unique gene^f
208596_s_at	UGT1A1-10	UDP glucuronosyltransferase 1 family, polypeptide A1-10	0.61	Not unique gene^d
201471_s_at	SQSTM1	Sequestosome 1	0.60	−1313, −345	(23)
210505_at	ADH7	Alcohol dehydrogenase 7	0.60	−2859	(19,23)
225609_at	GSR	Glutathione reductase	0.55	−9339, −12	(10,23,24)

^aNrf2 index was correlated with the expression values of all genes expressed in the lung of healthy smokers (“P call” in > 20 % of samples), the 25 probe sets representing the highest correlation are listed.
^bProbe set identification number (ID) based on Affymterix Human Genome U133 plus 2.0 Array.
^cLocation of primary core sequence (RTGAYNNNGCR) of the antioxidant response element (ARE) in base pairs (bp) upstream (minus) or down stream (plus) of transcription site by searching the promoter area of each gene with Genamics Expression 1.1 Pattern Finder Tool software.
^dProbe set does not represent a unique gene. It includes several members of UDP-glucuromosyltransferase family, including UGT1A1, UGT1A10, UGT1A3, UGT1A4, UHT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9.
^eNo antioxidant response element (ARE) identified with Genamics Expression 1.1 Pattern Finder Tool software
^fProbe set does not represent a unique gene. The transcribed locus lies between AKRC1 and AKRC2 genes.

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